Wolfram’s Syndrome is a genetic disorder. It is caused by a recessive allele (n). In people with Wolfram’s syndrome, a protein does not function correctly. The diagram shows a pair of chromosomes from a person called Tim. Meena is expecting a baby. Tim is the father. Complete this genetic diagram. Wolfram’s syndrome can affect the pancreas. Meena and Tim’s doctor tells them that there is a chance that their baby will have problems controlling their blood glucose level. Explain why the doctor thinks this. Use information from part (i) and your biological knowledge. – 7612

One thought on “Wolfram’s Syndrome is a genetic disorder. It is caused by a recessive allele (n). In people with Wolfram’s syndrome, a protein does not function correctly. The diagram shows a pair of chromosomes from a person called Tim. Meena is expecting a baby. Tim is the father. Complete this genetic diagram. Wolfram’s syndrome can affect the pancreas. Meena and Tim’s doctor tells them that there is a chance that their baby will have problems controlling their blood glucose level. Explain why the doctor thinks this. Use information from part (i) and your biological knowledge. – 7612”

1. Tim’s and Lucy’s genotypes are Nn. The Punnett square shows the possible offspring as NN, Nn, Nn, and nn. This means the baby could be nn, with a one-in-four chance of being affected.
   If the baby is affected, their pancreas won’t produce insulin. Insulin is needed to control the blood glucose level.

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